Multi-Scale Modeling in Rodent Ventricular Myocytes: Contributions of structural and functional heterogeneities to excitation-contraction coupling
نویسندگان
چکیده
Department of Bioengineering, UCSD, La Jolla, CA Department of Mathematics, UCSD, La Jolla, CA Department of Chemistry and Biochemistry, Department of Pharmacology, Howard Hughes Medical Institute, UCSD, La Jolla, CA National Biomedical Computation Resource, UCSD, La Jolla, CA National Center for Microscopic and Imaging Research, UCSD, CA Department of Medicine, UCSD, La Jolla, CA Department of Bioengineering, University of Illinois, Urbana-Champaign, IL Department of Biomedical Engineering, University of Virginia, VA
منابع مشابه
Studying dyadic structure–function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling
Excitation-contraction coupling in cardiac myocytes requires calcium influx through L-type calcium channels in the sarcolemma, which gates calcium release through sarcoplasmic reticulum ryanodine receptors in a process known as calcium-induced calcium release, producing a myoplasmic calcium transient and enabling cardiomyocyte contraction. The spatio-temporal dynamics of calcium release, buffer...
متن کاملA dynamic model of excitation-contraction coupling during acidosis in cardiac ventricular myocytes.
Acidosis in cardiac myocytes is a major factor in the reduced inotropy that occurs in the ischemic heart. During acidosis, diastolic calcium concentration and the amplitude of the calcium transient increase, while the strength of contraction decreases. This has been attributed to the inhibition by protons of calcium uptake and release by the sarcoplasmic reticulum, to a rise of intracellular so...
متن کاملA localized meshless approach for modeling spatial-temporal calcium dynamics in ventricular myocytes.
Spatial–temporal calcium dynamics due to calcium release, buffering and re-uptaking plays a central role in studying excitation–contraction (E–C) coupling in both normal and diseased cardiac myocytes. In this paper, we employ a meshless method, namely, the local radial basis function collocation method (LRBFCM), to model such calcium behaviors by solving a nonlinear system of reaction–diffusion...
متن کاملDynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes
The fidelity of excitation-contraction (EC) coupling in ventricular myocytes is remarkable, with each action potential evoking a [Ca²⁺](i) transient. The prevalent model is that the consistency in EC coupling in ventricular myocytes is due to the formation of fixed, tight junctions between the sarcoplasmic reticulum (SR) and the sarcolemma where Ca²⁺ release is activated. Here, we tested the hy...
متن کاملNo apparent requirement for neuronal sodium channels in excitation-contraction coupling in rat ventricular myocytes.
The majority of Na channels in the heart are composed of the tetrodotoxin (TTX)-resistant (KD, 2 to 6 micromol/L) "cardiac" NaV1.5 isoform; however, TTX-sensitive (KD, 1 to 25 nmol/L) "neuronal" Na channel isoforms have recently been detected in several cardiac preparations. In the present study, we determined the functional subcellular localization of Na channel isoforms (according to their TT...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008